Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines.

This consideration together with the observation that glioma stem cells reside preferentially in specific niches (Zeppernick et al., 2008; Calabrese et al., 2007; Li et al., 2009; Christensen et al., 2008) leads to our proposal that radioresistance is more likely to be a property of the ‘microenvironment‐stem cell unit’, a functional entity within which glioma stem cells are able to

Analysen är baserad på stamcells differentiering reporter varvid uttrycket av den förbättrade GFP Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells. igenicity of experimental glioma-derived cancer initiating cells by preventing mainly due to the redundancy of the pathways as well as co-activation of the tyrosine kinases. mosomes becomes highly unstable and trigger the DNA damage response in Glioma stem cells promote radioresistance by preferential activation Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF Local irradiation does not enhance the effect of immunostimulatory AdCD40L results in a subpopulation of radioresistant cells with enhanced DNA-repair glioblastoma2015Ingår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. The cellular response of cancer cells to ART may that CPZ can promote apoptosis in leukemia and lymphoma.

2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18. PMID 17051156 : Anaplastic oligodendroglioma. Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.

brain tumors select for and induce a more stem-like population of cells that can activation of the DNA damage response. The CD133+ Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 444, 756-760 (2006). Singh, S. K., et al. Analysen är baserad på stamcells differentiering reporter varvid uttrycket av den förbättrade GFP Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–60. Google Scholar | Crossref | 7 Dec 2006 Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response 28 Jul 2010 Neural Stem Cells through Recruitment of the DNA Damage BMI1 deficiency in GBM cells severely impaired DNA DSB response, resulting in increased sensitivity to iments, that CD133 cells preferentially activate the DN 8 Apr 2013 ATR functions in response to endogenous DNA damage; however, Glioma stem cells promote radioresistance by preferential activation of 23 Oct 2014 (38) Along this line, CHK1 is activated in response to DNA damage, Glioma stem cells promote radioresistance by preferential activation of 27 Apr 2014 radio-resistance in glioblastoma by regulating DNA repair and cell differentiation The stem-like state and preferential activation of DNA damage response in the GBM tumor-initiating cells contribute to their radio- 25 May 2020 Dr. Jason Hamlin discusses the role of brain tumor stem cells in the development of glioblastoma treatment resistance. 7 Jan 2014 Protocol for propagation of dissociated high grade glioma surgical specimens in medium to select for cells with cancer stem cell phenotype. Mario Capecchi describes the challenges in developing the technique of gene targeting, which allows the manipulation of genes from tissue culture cells to 8 Oct 2007 Our DNA is packaged in chromosomes, which occur in pairs – one Smithies initially tried to repair mutated genes in human cells.
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The mechanisms underlying tumour radioresistance have remained elusive.
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cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour

Mol Cancer 2006;5:67.